کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2406903 1103101 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Freezing temperatures in the vaccine cold chain: A systematic literature review
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Freezing temperatures in the vaccine cold chain: A systematic literature review
چکیده انگلیسی

The dangers of accidental freezing of vaccines in the cold chain have prompted studies throughout the globe to better characterize the risk. To date, there has been no systematic review of these studies. This analysis highlights that accidental freezing is pervasive and occurs across all segments of the cold chain. Between 14% and 35% of refrigerators or transport shipments were found to have exposed vaccine to freezing temperatures, while in studies that examined all segments of distribution, between 75% and 100% of the vaccine shipments were exposed. More rigorous study designs were associated with higher levels of freeze exposure. As more expensive, freeze-sensitive vaccines are introduced into immunization schedules, freeze prevention will become increasingly critical for ensuring that the world's children are receiving fully potent vaccine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 20, 16 May 2007, Pages 3980–3986
نویسندگان
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