کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408104 1103157 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus
چکیده انگلیسی

SummaryThe Japanese encephalitis virus (JEV) serocomplex-group consists of mosquito-borne flaviviruses, which include West Nile virus (WNV) and JEV, and both may cause severe encephalitis in humans. WNV has spread rapidly across the United States since its introduction in 1999 and its geographical distribution within the western hemisphere is expected to further expand, whereas, JEV is the most common cause of viral encephalitis in Southeast Asia, China and India. Currently, there is no registered human vaccine or specific therapy to prevent or treat WNV infection. Here we describe the efficacy of recombinant domain III (DIII) of WNV glycoprotein E in a mouse model. It induces high neutralizing antibody titers, as well as, protection against lethal WNV infection in C57BL/6 mice. This vaccine preparation also afforded partial protection against lethal JEV infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issue 2, 10 January 2008, Pages 153–157
نویسندگان
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