کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2408507 | 1103177 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of H-2d restricted Th epitopes in Urease B subunit of Helicobacter pylori
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
CD4+ T cells play important roles in protection against Helicobacter pylori (H. pylori) infection. In order to better understand the immune responses of H. pylori infection and improve immune interventions against this pathogen, we identified the Th epitopes in UreB of H. pylori, an excellent vaccine candidate antigen. By using the RANKPEP prediction algorithm, we have identified and characterized three Th epitopes within the UreB antigen, which can be recognized by CD4+ T cells from BALB/c (H-2d) mice. They were U546–561, U229–244, and U237–251. These epitopes have important value for studying the immune response of H. pylori infection and for designing effective vaccine against H. pylori.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 14, 30 March 2007, Pages 2583–2590
Journal: Vaccine - Volume 25, Issue 14, 30 March 2007, Pages 2583–2590
نویسندگان
Yun Shi, Chao Wu, Wei-Ying Zhou, Xu-Hu Mao, Gang Guo, Quan-Ming Zou,