کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2408507 1103177 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of H-2d restricted Th epitopes in Urease B subunit of Helicobacter pylori
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Identification of H-2d restricted Th epitopes in Urease B subunit of Helicobacter pylori
چکیده انگلیسی

CD4+ T cells play important roles in protection against Helicobacter pylori (H. pylori) infection. In order to better understand the immune responses of H. pylori infection and improve immune interventions against this pathogen, we identified the Th epitopes in UreB of H. pylori, an excellent vaccine candidate antigen. By using the RANKPEP prediction algorithm, we have identified and characterized three Th epitopes within the UreB antigen, which can be recognized by CD4+ T cells from BALB/c (H-2d) mice. They were U546–561, U229–244, and U237–251. These epitopes have important value for studying the immune response of H. pylori infection and for designing effective vaccine against H. pylori.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 14, 30 March 2007, Pages 2583–2590
نویسندگان
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