کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2408519 | 1103177 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cryptic B-cell epitope identification through informational analysis of protein sequenses
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cryptic B-cell epitope identification through informational analysis of protein sequenses Cryptic B-cell epitope identification through informational analysis of protein sequenses](/preview/png/2408519.png)
چکیده انگلیسی
A comparison of the location of B-cell epitopes and information structure (IS) of protein sequences was attempted. Analysis of 62 known B-cell epitopes located in five different proteins showed that they concentrated in IS sites with increased degree of information coordination. Based on the analysis of IS six peptides from two proteins were selected and produced in a recombinant form as yeast virus-like particles (VLPs). Immunization of mice with recombinant VLP-peptides has induced the production of IgG capable of recognizing full-length antigens. This result suggests that the analysis of IS of proteins can be useful in the selection of peptides possessing cryptic B-cell epitope activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 14, 30 March 2007, Pages 2688-2697
Journal: Vaccine - Volume 25, Issue 14, 30 March 2007, Pages 2688-2697
نویسندگان
Ludmila Alekseeva, Aleksei Nekrasov, Aleksei Marchenko, Marina Shevchenko, Sergei Benevolenskii, Alexander Sapozhnikov, Viswanath P. Kurup, Elena Svirshchevskaya,