کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409048 1103204 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models
چکیده انگلیسی

We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 46, 14 November 2007, Pages 7955–7961
نویسندگان
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