کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2409554 | 1103222 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The identification of new adjuvants is a critical need in vaccinology. In this work, it is demonstrated that bis-(3′,5′)-cyclic dimeric guanosine monophosphate (cdiGMP) exhibits potent adjuvant properties. Subcutaneous co-administration of cdiGMP with β-galactosidase (β-Gal) to mice resulted in the elicitation of significantly higher antigen-specific serum IgG titres than in animals receiving β-Gal alone. Strong cellular immune responses, which were characterized by a balanced Th1/Th2 pattern, were also observed in response to the β-Gal protein and a peptide encompassing its MHC class I-restricted epitope in immunized animals. These results suggest that cdiGMP represents a promising adjuvant for vaccine development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 8, 9 February 2007, Pages 1464–1469
Journal: Vaccine - Volume 25, Issue 8, 9 February 2007, Pages 1464–1469
نویسندگان
Thomas Ebensen, Kai Schulze, Peggy Riese, Claudia Link, Michael Morr, Carlos A. Guzmán,