کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2409604 1103224 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vaccination against the feline leukaemia virus: Outcome and response categories and long-term follow-up
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Vaccination against the feline leukaemia virus: Outcome and response categories and long-term follow-up
چکیده انگلیسی

Feline leukaemia virus (FeLV) is a pathogen inducing fatal disease in cats worldwide. By applying sensitive molecular assays, efficacious commonly used FeLV vaccines that protect cats from antigenaemia were found not to prevent proviral integration and minimal viral replication after challenge. Nonetheless, vaccines protected cats from FeLV-associated disease and prolonged life expectancy. The spectrum of host response categories was refined by investigating plasma viral RNA loads. All cats initially fought similar virus loads, although subsequently loads were associated with infection outcomes. Persistence of plasma viral RNA was moderately associated with reactivation of FeLV infection. In conclusion, sensitive molecular assays are important tools for reviewing pathogenesis of FeLV infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 30, 26 July 2007, Pages 5531–5539
نویسندگان
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