کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2410373 1103258 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunization with pseudorabies virus harboring Fc domain of IgG makes a contribution to protection of mice from lethal challenge
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Immunization with pseudorabies virus harboring Fc domain of IgG makes a contribution to protection of mice from lethal challenge
چکیده انگلیسی

To enhance the efficacy of an inactivated vaccine against pseudorabies virus (PRV), we evaluated the adjuvant properties of Fc domain of IgG. A cell line expressing mouse IgG Fc chimera on its surface was established. We found that when PRV was propagated in the cells expressing the Fc chimera, PRV virion incorporated the Fc. Immunization of BALB/c mice with inactivated PRV harboring Fc, which had been propagated in the cells expressing Fc on its surface, induced higher antibody production against PRV and protected mice more effectively from lethal challenge of virulent strain, comparing to the immunization with normal inactivated virus. Virus harboring Fc has a great potential as a new inactivated vaccine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issue 29, 31 May 2005, Pages 3775–3782
نویسندگان
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