کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2410845 1103284 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved intranasal immunization with live-attenuated measles virus after co-inoculation of the lipopeptide MALP-2
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Improved intranasal immunization with live-attenuated measles virus after co-inoculation of the lipopeptide MALP-2
چکیده انگلیسی

The macrophage-activating lipopeptide with a molecular weight of 2 kDa (MALP-2) activates antigen presenting cells of human, mouse and rat origin in vitro and in vivo. Here, we demonstrate that MALP-2 induces MIP1α and β, MIP-2, Gro, TNFα, IL1α and IL6 in cells of cotton rats (Sigmodon hispidus) in vitro. Intranasal inoculation into cotton rats leads to migration of neutrophils and other leucocytes into the lung lumen and lung tissue. After intranasal co-inoculation of MALP-2 with live-attenuated measles vaccine virus, higher titers of neutralizing antibodies are induced but the proliferative T cell response did not increase. Immunization leads to protective immunity in the absence, but not in the presence of passively transferred measles virus (MV) specific antibodies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issue 39, 15 September 2005, Pages 4721–4726
نویسندگان
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