کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2467435 1555391 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Experimental infection of cattle, sheep and pigs with ‘Hobi’-like pestivirus
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Experimental infection of cattle, sheep and pigs with ‘Hobi’-like pestivirus
چکیده انگلیسی

To date, limited information is available on the ability of ‘Hobi’-like pestiviruses (putative bovine viral diarrhoea 3) to infect and cause disease in animal species traditionally affected by pestiviruses. In order to obtain new insights into host range and pathogenic potential of this atypical pestivirus, BVDV-seronegative calves (n = 5), lambs (n = 5) and piglets (n = 5) were experimentally infected with the European ‘Hobi’-like strain Italy-1/10-1, whereas two animals per species served as uninfected controls. Appearance of clinical signs, leukopenia, viremia, viral shedding and seroconversion were monitored for 28 days post-infection. Calves and lambs were successfully infected, displaying respiratory signs (nasal discharge), moderate hyperthermia and leukopenia, viremia and viral shedding through the nasal and faecal routes. Antibody responses were observed in both animal species by ELISA and virus neutralisation assays. In contrast, inoculated piglets did not display any clinical signs nor leukopenia and viral RNA was not detected in any biological samples. Nevertheless, the presence of detectable antibodies by virus neutralisation accounted for a successful, albeit limited infection of these animals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 155, Issues 2–4, 23 March 2012, Pages 165–171
نویسندگان
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