کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484527 | 1114314 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Designed Blending for Near Infrared Calibration
ترجمه فارسی عنوان
طراحی مخلوط برای کالیبراسیون نزدیک به مادون قرمز
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کلمات کلیدی
طیف سنجی نزدیک به مادون قرمز، حداقل مربعات جزئی، طراحی فاکتوریل تکنولوژی پودر، مهندسی داروسازی،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Spectroscopic methods are increasingly used for monitoring pharmaceutical manufacturing unit operations that involve powder handling and processing. With that regard, chemometric models are required to interpret the obtained spectra. There are many ways to prepare artificial powder blend samples used in a chemometric model for predicting the chemical content. Basically, an infinite number of possible concentration levels exist in terms of the individual components. In our study, design of experiments for ternary mixtures was used to establish a suitable number of blend compositions that represents the entire mixture region of interest for a three component blend. Various experimental designs and their effect on the predictive power of a chemometric model for near infrared spectra were investigated. It was determined that a particular choice of experimental design could change the predictive power of a model, even with the same number of calibration experiments. (C 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:2312-2322, 2015
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 7, July 2015, Pages 2312-2322
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 7, July 2015, Pages 2312-2322
نویسندگان
Otto Scheibelhofer, Bianca Grabner, Robert W. Jr., Benoît Igne, Stephan Sacher, Johannes G. Khinast,