کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484682 | 1114322 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicin
ترجمه فارسی عنوان
میکرومولسیون بیو سازگار تغییر توزیع بافت دوکسوروبیسین را تغییر می دهد
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The incorporation of doxorubicin (DOX) in a microemulsion (DOX-ME) has shown beneficial consequences by reducing the cardiotoxic effects of DOX. The aim of this study was to determine the distribution of DOX-ME in Ehrlich solid tumor (EST) and the heart, and compare it with that of free DOX. The distribution study was conducted with female Swiss mice with EST (n = 7 per group; 20-25 g). Animals received a single dose (10 mg/kg, i.p.) of DOX or DOX-ME 7 days after tumor inoculation. Fifteen minutes after administration, the animals were sacrificed, and the tumor and heart tissues were taken for immediate analysis by ultra-performance liquid chromatography. No difference was observed in DOX concentration in tumor tissue between DOX and DOX-ME administration. However, the most remarkable result in this study was the statistically significant reduction in DOX concentration in heart tissue of animals given DOX-ME. Mean DOX concentration in heart tissue was 0.92 ± 0.54 ng mgâ1 for DOX-ME and 1.85 ± 0.34 ng mgâ1 for free DOX. In conclusion, DOX-ME provides a better tissue distribution profile, with a lower drug concentration in heart tissue but still comparable tumor drug concentration, which indicates that antitumor activity would not be compromised. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3297-3301, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 10, October 2014, Pages 3297-3301
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 10, October 2014, Pages 3297-3301
نویسندگان
Caroline Damico Candido, Michel Leandro Campos, Juliana Uruguay Correa Vidigal Assumpção, Kelly Chrystina Pestana, Elias Carvalho Padilha, Iracilda Zeppone Carlos, Rosângela Gonçalves Peccinini,