کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484798 | 1114337 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solid Dispersions Prepared by Continuous Cogrinding in an Air Jet Mill
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کلمات کلیدی
Surface energy - انرژی سطحیPhysicochemical properties - خواص فیزیکی و شیمیاییPoorly water-soluble drugs - داروهای محلول در آب بسیار ضعیف استRaman spectroscopy - طیف سنجی رامانMilling - فِرِزکاری Dissolution rate - نرخ انحلالX-ray powder diffractometry - پراش اشعه ایکس پراشSolid dispersion - پراکندگی جامدCalorimetry (DSC) - کالریمتری (DSC)
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Embedding a poorly water-soluble drug as a solid dispersion in a hydrophilic carrier by cogrinding is a possible strategy for enhancing the drug dissolution rate. Although general interest in continuous processes for manufacturing drug formulations has increased, many publications still focus on batch processes. The jet mill used in this study is a promising tool for continuous cogrinding. Investigation of different drug-to-carrier ratios (griseofulvin/mannitol) demonstrated that a drug load of 10% is best suited to investigate the enhanced dissolution behavior. To gain deeper insight into the underlying mechanisms, the coground dispersion is compared with different physical mixtures in terms of physicochemical properties and dissolution behavior. Differential scanning calorimetry and X-ray powder diffraction were used to verify the crystalline structure of the coground formulation. On the basis of the Hixson-Crowell model, particle size reduction was ruled out as the main reason for dissolution enhancement. An increase of surface free energies because of grinding is shown with contact angle measurements. Confocal Raman microscopy investigations revealed the drug's bulk dispersity in the coground formulation as an additional factor for the increased dissolution rate. In conclusion, the continuous cogrinding approach is a promising technique to prepare the drug in a rapidly dissolving, yet crystalline, form.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 11, November 2013, Pages 4132-4139
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 11, November 2013, Pages 4132-4139
نویسندگان
Christian Muehlenfeld, Birthe Kann, Maike Windbergs, Markus Thommes,