کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484891 | 1114339 | 2012 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Applying the taguchi method to optimize sumatriptan succinate niosomes as drug carriers for skin delivery
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کلمات کلیدی
HPLC (high‐performance/pressure liquid chromatography)Extrusion - اکستروژنTransdermal drug delivery - تحویل داروی ترانزیستورPermeation enhancers - تقویت کننده نفوذSurfactants - سورفکتانتها یا مواد فعال سطحیFactorial design - طراحی فاکتوریلLiposomes - لیپوزومCationic lipids - لیپیدهای کاتیونیlight scattering (dynamic) - پراکندگی نور (پویا)Skin - پوست
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Niosomes formulated from different nonionic surfactants (Span® 60, Brij® 72, Span® 80, or Eumulgin® B 2) with cholesterol (CH) molar ratios of 3:1 or 4:1 with respect to surfactant were prepared with different sumatriptan amount (10 and 15âmg) and stearylamine (SA). Thinâfilm hydration method was employed to produce the vesicles, and the time lapsed to hydrate the lipid film (1 or 24âh) was introduced as variable. These factors were selected as variables and their levels were introduced into two L18 orthogonal arrays. The aim was to optimize the manufacturing conditions by applying Taguchi methodology. Response variables were vesicle size, zeta potential (Z), and drug entrapment. From Taguchi analysis, drug concentration and the time until the hydration were the most influencing parameters on size, being the niosomes made with Span® 80 the smallest vesicles. The presence of SA into the vesicles had a relevant influence on Z values. All the factors except the surfactant-CH ratio had an influence on the encapsulation. Formulations were optimized by applying the marginal means methodology. Results obtained showed a good correlation between mean and signalâtoânoise ratio parameters, indicating the feasibility of the robust methodology to optimize this formulation. Also, the extrusion process exerted a positive influence on the drug entrapment. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:3845-3863, 2012
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 10, October 2012, Pages 3845-3863
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 10, October 2012, Pages 3845-3863
نویسندگان
Maria Luisa GonzálezârodrÃguez, Imane Mouram, Ma Jose Cózarâbernal, Sheila Villasmil, Antonio M. Rabasco,