کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484917 | 1114340 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of 14N NQR to the Study of Piroxicam Polymorphism
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
A study was conducted to test the capability of the 14N nuclear quadrupole resonance (NQR) method to discriminate qualitatively and quantitatively among different forms of piroxicam. Samples of commercial piroxicam form I and its monohydrate were obtained on the local market. Additionally, samples of form I and II were prepared by recrystallization in 1,2-dichloroethane and ethanol, respectively. DSC and FT-IR were employed as reference methods. A14N NQR spectrometer was used to measure samples of different forms and mixtures of piroxicam at 2587 and 3439Â kHz. DSC and FT-IR clearly confirmed differences between the different piroxicam forms. Measurements of 14N NQR signals of different forms of piroxicam at 2587Â kHz detected only spectral peaks of form I. The dependence of 14N NQR signal intensity on the concentration of form I in mixtures with the monohydrate showed a clear linear relationship at both measured frequencies, though the scattering of data was greater at 3439Â kHz due to the lower S/N ratio. The 14N NQR method has the potential to become an additional and important spectroscopic tool in the study of solid-state forms, not only of pure active pharmaceutical ingredients or excipients, but also of their mixtures. This ability lends the method to a possible successful utilization at different levels of pharmaceutical manufacturing and product quality control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 12, December 2010, Pages 4857-4865
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 12, December 2010, Pages 4857-4865
نویسندگان
Zoran Lavric, Janez Pirnat, Janko Luznik, Janez Seliger, Veselko Zagar, Zvonko Trontelj, Stane Srcic,