کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485018 | 1114343 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rapid Deamidation of Recombinant Protective Antigen when Adsorbed on Aluminum Hydroxide Gel Correlates with Reduced Potency of Vaccine
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Rapid Deamidation of Recombinant Protective Antigen when Adsorbed on Aluminum Hydroxide Gel Correlates with Reduced Potency of Vaccine Rapid Deamidation of Recombinant Protective Antigen when Adsorbed on Aluminum Hydroxide Gel Correlates with Reduced Potency of Vaccine](/preview/png/2485018.png)
چکیده انگلیسی
Deamidation of the recombinant protective antigen (rPA) correlates with decreased effectiveness of the vaccine in protecting against infection by Bacillus anthracis. We present data demonstrating dramatic deamidation of amino acid positions 713 and 719 of rPA adsorbed onto aluminum hydroxide gel, an adjuvant, relative to rPA stored in solution without adjuvant. Although deamidation did not impact total levels of rPA-specific antibodies in a mouse model, it did correlate with a decrease in toxin-neutralizing antibodies. On the basis of these data, we hypothesize that interactions of rPA with aluminum hydroxide gel are destabilizing and are the direct cause of reduced vaccine efficacy. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:454-461, 2013
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 2, February 2013, Pages 454-461
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 2, February 2013, Pages 454-461
نویسندگان
Ajit Joseph M. D'Souza, Kevin D. Mar, Joanne Huang, Sumit Majumdar, Brandi M. Ford, Beverly Dyas, Robert G. Ulrich, Vincent J. Sullivan,