کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2485100 1114345 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of phospholipid and liposomal S-adenosyl methionine for the treatment of liver injury in a murine model
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Evaluation of phospholipid and liposomal S-adenosyl methionine for the treatment of liver injury in a murine model
چکیده انگلیسی
We have used a murine model of Acetaminophen induced hepatoxicity to determine if S-adenosyl methionine 1,4 butanedisulfonate (SD4) in liposomes can prevent liver injury when administered immediately prior to acetaminophen, as judged by serum aspartate aminotransferase and alanine aminotransferase levels, and histological evidence of liver necrosis. No protection was observed when mice received 1 g/kg unencapsulated SD4. Partial protection was observed with 5 or 0.5 mg/kg SD4 in unextruded distearoylphosphatidylglycerol (DSPG) liposomes. Protection comparable to that seen in mice receiving encapsulated SD4 is achieved when mice received lipid alone in equivalent amounts, suggesting that the contribution of encapsulated SD4 to the efficacy of the liposomes may be minimal. Unextruded distearoylphosphatidylcholine (DSPC) liposomes show only slight effects even at 50 mg/kg SD4. This is likely caused by the size of unextruded DSPC lipsomes, because extruded DSPC liposomes, whose size is smaller, are of comparable efficacy to unextruded DSPG liposomes. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1800-1809, 2010
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 4, April 2010, Pages 1800-1809
نویسندگان
, , , , , ,