کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485122 | 1114345 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Limitations of amorphous content quantification by isothermal calorimetry using saturated salt solutions to control relative humidity: Alternative methods
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Limitations of amorphous content quantification by isothermal calorimetry using saturated salt solutions to control relative humidity: Alternative methods Limitations of amorphous content quantification by isothermal calorimetry using saturated salt solutions to control relative humidity: Alternative methods](/preview/png/2485122.png)
چکیده انگلیسی
Despite the high sensitivity of isothermal calorimetry (IC), reported measurements of amorphous content by this technique show significant variability even for the same compound. An investigation into the reasons behind such variability is presented using amorphous lactose and salbutamol sulfate as model compounds. An analysis was carried out on the heat evolved as a result of the exchange of water vapor between the solid sample during crystallization and the saline solution reservoir. The use of saturated salt solutions as means of control of the vapor pressure of water within sealed ampoules bears inherent limitations that lead in turn to the variability associated with the IC technique. We present an alternative IC method, based on an open cell configuration that effectively addresses the limitations encountered with the sealed ampoule system. The proposed approach yields an integral whose value is proportional to the amorphous content in the sample, thus enabling reliable and consistent quantifications. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 2080-2089, 2010
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 4, April 2010, Pages 2080-2089
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 4, April 2010, Pages 2080-2089
نویسندگان
Nawel Khalef, Rodolfo Pinal, Aziz Bakri,