کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485161 | 1114346 | 2012 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Arterial Pharmacokinetics of Red Wine Polyphenols: Implications for Novel Endovascular Therapies Targeting Restenosis
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Arterial Pharmacokinetics of Red Wine Polyphenols: Implications for Novel Endovascular Therapies Targeting Restenosis Arterial Pharmacokinetics of Red Wine Polyphenols: Implications for Novel Endovascular Therapies Targeting Restenosis](/preview/png/2485161.png)
چکیده انگلیسی
Drug-eluting stents (DESs) are endovascular devices that provide controlled release of compounds to interfere with restenosis, an adverse outcome of angioplasty characterized by thickening of the arterial wall. Accumulating evidence suggests that arterial pharmacokinetics determine the biological effect and potential toxicity of stent-based therapeutics. The aim of this study was to examine how drug polarity, drug load, and protein binding influence release from a polymer film and distribution within arterial tissue. The transport and safety profile of resveratrol (RESV) and quercetin (QUER), two red wine polyphenols known to interfere with events in the pathogenesis of restenosis, were compared with paclitaxel (Taxol), a lipophilic drug used in DES. In bovine arteries, RESV showed considerable protein binding and arterial kinetics that were found to mimick Taxol. In contrast, the less lipophilic QUER showed limited tissue distribution. Measured diffusivity of RESV and QUER was coupled with a novel computational method for assessment of biphasic drug release kinetics and arterial drug retention profiles. Modeling revealed that drugs associated with high- and low-protein-binding affinity result in markedly distinct arterial drug profiles. These data underscore the importance of arterial partitioning and propagation of drug within arterial tissue in the rational design of DES coatings. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1917-1931, 2012
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 5, May 2012, Pages 1917-1931
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 5, May 2012, Pages 1917-1931
نویسندگان
James J. Kleinedler, Ilija Pjescic, Kirby K. Bullock, Abdul Khaliq, John D. Foley, Tammy R. Dugas,