کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485237 | 1114350 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Detection of a Minor Amorphous Phase in Crystalline Etoricoxib by Dynamic Mechanical Analysis: Comparison with Raman Spectroscopy and Modulated Differential Scanning Calorimetry
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کلمات کلیدی
DMAMDSCAmorphous - آمورفThermal analysis - آنالیز حرارتیEtoricoxib - اتریکوکسیبGlass transition - انتقال شیشهDynamic mechanical analysis - تجزیه و تحلیل مکانیکی پویاCrystalline - جامد کریستالی، کریستالRaman spectroscopy - طیف سنجی رامانlimit of detection - محدودیت تشخیصModulated differential scanning calorimetry - کالوریمتری اسکن کوانتومی مدولاسیون شده
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Detection of a Minor Amorphous Phase in Crystalline Etoricoxib by Dynamic Mechanical Analysis: Comparison with Raman Spectroscopy and Modulated Differential Scanning Calorimetry Detection of a Minor Amorphous Phase in Crystalline Etoricoxib by Dynamic Mechanical Analysis: Comparison with Raman Spectroscopy and Modulated Differential Scanning Calorimetry](/preview/png/2485237.png)
چکیده انگلیسی
Detection and quantification of the amorphous phase of etoricoxib bulk drug substances, a selective cycloogenase-2 inhibitor used for the treatment of osteoarthritis, rheumatoid arthritis, and dental pain, was carried out using modulated differential scanning calorimetry (MDSC), dynamic mechanical analysis (DMA), and Raman spectroscopy. Detection of amorphous content in pharmaceutical powders by DMA is a special application of dynamic mechanical spectroscopy. DMA was found to be a sensitive technique, able to detect the presence of an amorphous phase in a crystalline phase at concentrations as low as 0.5%. The limit of detection (LOD) determined for DMA was 2.5%. In comparison, Raman spectroscopy and MDSC had LOD values of 2% and 5% amorphous, respectively. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 2, February 2012, Pages 558-565
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 2, February 2012, Pages 558-565
نویسندگان
Sophie-Dorothee Clas, Karine Lalonde, Karine Khougaz, Chad R. Dalton, Rana Bilbeisi,