کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485238 | 1114350 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Liposomes Coated with Chitosan-Xanthan Gum (Chitosomes) as Potential Carriers for Pulmonary Delivery of Rifampicin
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Liposomes Coated with Chitosan-Xanthan Gum (Chitosomes) as Potential Carriers for Pulmonary Delivery of Rifampicin Liposomes Coated with Chitosan-Xanthan Gum (Chitosomes) as Potential Carriers for Pulmonary Delivery of Rifampicin](/preview/png/2485238.png)
چکیده انگلیسی
The aim of this work was to develop new microparticles for drug delivery to lungs by coating liposomes with chitosan (CH)-xanthan gum (XG) polyelectrolyte complexes to obtain chitosomes. To this purpose, two groups of liposomes were prepared using a mixture of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine in two different concentrations to evaluate their capability to entrap appropriate amounts of the model drug rifampicin. The obtained vesicles were then coated with different CH-XG weight ratios and liposomes and chitosomes were characterized in terms of morphology, size, size distribution, zeta potential, drug entrapment, and rheological properties. The efficiency of chitosomes and liposomes during nebulization was also studied. Results of this study indicated that nebulization and rheological properties of chitosomes are affected by the CH-XG weight ratio. In particular, CH-XG 1:0.5 (w/w) coating was able to greatly improve drug total mass output and drug deposition in the lower stages of the impinger. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 2, February 2012, Pages 566-575
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 2, February 2012, Pages 566-575
نویسندگان
Maria Letizia Manca, Maria Manconi, Donatella Valenti, Francesco Lai, Giuseppe Loy, Pietro Matricardi, Anna Maria Fadda,