کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485291 | 1114351 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel amorphous microporous silica spheres for controlled release applications
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
A new synthesis route for large spherical particles of amorphous microporous silica (AMS) was developed. These novel spherical porous particles with diameter of around 100 µm and pore diameter smaller than 2 nm were prepared using an oil drop method. Molten ibuprofen was successfully loaded into the AMS pores. In vitro release experiments revealed that ibuprofen was released from the spheres via a slow pore diffusion process lasting up to 14 days. Experimentally determined diffusion coefficients of ibuprofen in the porous spheres were of the order of 10â15-10â16 m2 sâ1. The present findings reveal the potential of AMS spheres for controlled release of small drug molecules over long time periods. The spherical shape of the AMS particles is advantageous in formulation processes as it provides adequate powder flow properties and reliable release profiles. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:4295-4301, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 10, October 2011, Pages 4295-4301
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 10, October 2011, Pages 4295-4301
نویسندگان
Els Verraedt, Guy Van den Mooter, Johan A. Martens,