کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | ترجمه فارسی | نسخه تمام متن |
---|---|---|---|---|---|
2485413 | 1114354 | 2012 | 8 صفحه PDF | سفارش دهید | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carbon-Deuterium Rotational-Echo Double-Resonance NMR Spectroscopy of Lyophilized Aspartame Formulations
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
In this study, changes in the local conformation of aspartame were observed in annealed lyophilized glasses by monitoring changes in the distance between two labeled sites using C-2H rotational-echo double-resonance (REDOR) nuclear magnetic resonance (NMR) spectroscopy. Confirmation that the REDOR experiments were producing accurate distance measurement was ensured by measuring the 13C-15N distance in glycine. The experiment was further verified by measuring the REDOR dephasing curve on 13C-2H methionine. 13C-2H REDOR dephasing curves were then measured on lyophilized aspartame-disaccharide formulations. In aspartame-sucrose formulation, the internuclear distances increased upon annealing, which correlated with decreased chemical reactivity. By contrast, annealing had only a minimal effect on the dephasing curve in aspartame-trehalose formulation. The results show that stability is a function of both mobility and local structure (conformation), even in a small molecule system such as lyophilized aspartame-sucrose. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:283-290, 2012
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 1, January 2012, Pages 283-290
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 1, January 2012, Pages 283-290
نویسندگان
Suman A. Luthra, Marcel Utz, Eric M. Gorman, Michael J. Pikal, Eric J. Munson, Joseph W. Lubach,
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