کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485650 | 1114362 | 2012 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and Optimization of SelfâNanoemulsifying Drug Delivery System with Enhanced Bioavailability by Box-Behnken Design and Desirability Function
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کلمات کلیدی
SNEDDSDissolution - انحلال Solubility - انحلال پذیریParticle size - اندازه ذراتOptimization - بهينه سازيDesirability function - تابع مطلوبیتBiopharmaceutics Classification System (BCS) - سیستم طبقه بندی بیولوژیک (BCS)Box–Behnken design - طرح جعبه BehnkenBioavailability - فراهم زیستیFlurbiprofen - فلوریدپروفن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development and Optimization of SelfâNanoemulsifying Drug Delivery System with Enhanced Bioavailability by Box-Behnken Design and Desirability Function Development and Optimization of SelfâNanoemulsifying Drug Delivery System with Enhanced Bioavailability by Box-Behnken Design and Desirability Function](/preview/png/2485650.png)
چکیده انگلیسی
The aim of our study was to characterize and optimize a selfânanoemulsifying drug delivery system (SNEDDS) formulation by a threeâfactor, threeâlevel Box-Behnken design (BBD) combined with a desirability function. The independent factors were the amounts of Capryol PGMC (X1), Tween 20 (X2), and Transcutol HP (X3). The dependent variables were droplet size (Y1), equilibrium solubility (Y2), and cumulative percentage of drug released in 15Â min (Y3) from the SNEDDS formulation. The responses were fitted to a secondâorder quadratic model and statistical validation of the fitted models was carried out by analysis of variance. Various response surface graphs and contour plots were constructed to understand the effects of different factor level combinations on the responses. The optimized SNEDDS formulation consisting of Capryol PGMC-Tween 20-Transcutol HP at proportions of 5:58.4:40 (w/w) was prepared and a comparison of the predicted values and experimental values was found to be in close agreement. Furthermore, an in vivo pharmacokinetic study of the optimized SNEDDS formulation showed a 2.2âfold increase in relative oral bioavailability compared with that of the suspension. In conclusion, the BBD demonstrated its effectiveness in optimizing the SNEDDS formulation and in understanding the effects of formulation variables on the performance of SNEDDS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 12, December 2012, Pages 4584-4596
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 12, December 2012, Pages 4584-4596
نویسندگان
Nirmal Marasini, Yi Dong Yan, Bijay Kumar Poudel, HanâGon Choi, Chul Soon Yong, Jong Oh Kim,