کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485666 | 1114363 | 2008 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pediatric Drugs-A Review of Commercially Available Oral Formulations
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کلمات کلیدی
ODT, orally disintegrating tabletHPC, hydroxypropylcelluloseAUC, Area-under-the-curve - AUC، Area-under-the-curvert, room temperature - RT، دمای اتاقEDTA, ethylenediaminetetraacetic acid - اتیلن دی آمین تترا استیک اسیدPediatric - اطفالUK, United Kingdom - انگلستان، انگلستانUSA, United States of America - ایالات متحده آمریکا، ایالات متحده آمریکاOral drug delivery - تحویل داروی خوراکیsolid-state stability - ثبات حالت جامدPhysical stability - ثبات فیزیکیFDA, Food and Drug Administration - سازمان غذا و دارو (آمریکا)Suspensions - سیستم های تعلیقExcipients - عضلاتRegulatory science - علم مقرراتSolid dosage form - فرم دوز جامدFormulation - فرمولاسیونHBV, Hepatitis B virus - ویروس هپاتیت بی Chemical stability - پایداری شیمیاییPEG, polyethylene glycol - پلیاتیلن گلیکول
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pediatric oral formulations can be quite scientifically challenging to develop and the prerequisites for both a measurable dosage form to administer based upon body-weight, and also taste-masking are two of the challenges unique for pediatric oral formulations. The physicochemical and organoleptic properties of the active drug substance such as solubility, chemical stability, and taste along with the intended dose can determine which formulations are feasible to develop. Oral pediatric formulations are available in 17 different varieties and can be either a ready-to-use formulation such as a solution, syrup, suspension, tablet, scored tablet, chewable tablet, orally disintegrating tablet, or thin strip, or can also be a formulation that requires manipulation such as a powder for constitution to a suspension, tablet for constitution to a suspension, powder for constitution to a solution, drops for reconstitution to a suspension, concentrated solution for dilution, effervescent tablet, bulk oral granules, bulk oral powder, or solid in a capsule to mix with food or drink. Recently there has been an increase in pediatric formulation development inspired by increased regulatory incentives. The intent of this review is to educate the reader on the various types of formulations administered orally to pediatrics, the rationale in deciding which type of formulation to develop, the excipients used, development challenges, the in-use handling of oral pediatric formulations, and the regulatory incentives. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97: 1731-1774, 2008
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 5, May 2008, Pages 1731-1774
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 5, May 2008, Pages 1731-1774
نویسندگان
Robert G. Strickley, Quynh Iwata, Sylvia Wu, Terrence C. Dahl,