Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model

The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in the fasted state showed that the rank order of the ASD estimated bioavailabilities is as follows: Form III > Form I > dihydrate. This result is in excellent agreement with those found in literature. Additional simulations comparing different gastric transit times during fasted and fed states are also discussed. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association