کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486399 1114382 2009 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Effect of Starch Material, Encapsulated Protein and Production Conditions on the Protein Release from Starch Microspheres
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
The Effect of Starch Material, Encapsulated Protein and Production Conditions on the Protein Release from Starch Microspheres
چکیده انگلیسی
The present study describes the preparation of 11 batches of starch microspheres for drug delivery. Parameters such as the type of starch material, the type of protein, and the incubation time of the process were varied, and the obtained microspheres differed in yield, encapsulation efficiency and physical properties. The crystalline/ordered structure (obtained through X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC)), the microscopic appearance and the surface morphology (viewed with scanning electron microscopy (SEM)) were found to differ between the batches depending on the starch type, encapsulated protein and incubation conditions that were employed. Freeze-drying was found to have a destructive effect on the ordered structure of the starch and this effect varied with regard to preparation conditions. Drug release experiments demonstrated that the release from the starch matrix depended on the type of protein as well as on the incubation time during the manufacturing at temperatures of 6°C and 37°C. The enzymatic degradation of starch was slightly different between the materials depending on the crystalline/ordered structure that had formed during the preparation. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3802-3815, 2009
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 10, October 2009, Pages 3802-3815
نویسندگان
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