کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486438 1114383 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lactoferrin-Conjugated Dendritic Nanoconstructs for Lung Targeting of Methotrexate
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Lactoferrin-Conjugated Dendritic Nanoconstructs for Lung Targeting of Methotrexate
چکیده انگلیسی
The present investigation was aimed at developing and exploring the potential of lactoferrin (Lf)-conjugated dendritic nanocomposite for lung targeting of methotrexate (MTX). The 5.0G poly(propylene imine) (PPI) dendrimer and Lf-conjugated 5.0G PPI dendrimer were synthesized and characterized by Fourier-transform infrared spectroscopy, nuclear magnetic resonance, and transmission electron microscopy . The entrapment efficiency, in vitro release, and hemolytic toxicity were assessed. Pharmacokinetic and organ distribution studies were carried out to evaluate in vivo targeting potential of developed system. The pharmacokinetic studies showed that elimination half-life of MTX-loaded plain PPI dendrimer (10.41 ± 2.12 h, p < 0.05) and MTX-loaded Lf-conjugated PPI dendrimer (12.23 ± 1.53 h, p < 0.01) was significantly higher than the free drug (5.85 ± 1.19 h). Organ distribution assessment of different formulations displayed significant (p < 0.05) higher accumulation of drug in lungs by MTX-Lf-PPI (1329 ± 26.7 ng/g of tissue) as compared with MTX-PPI (721 ± 23.4 ng/g of tissue) and free MTX (575 ± 19.7 ng/g of tissue) after 6 h of administration. The result suggested that Lf-conjugated 5.0G PPI dendrimer-based formulations to be approximately 1.5 times and 2.5 times superior to plain 5.0G PPI dendrimer as well as pure MTX, respectively, for lung targeting of anticancer drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 6, June 2011, Pages 2311-2320
نویسندگان
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