کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486451 | 1114383 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monitoring of Antisolvent Crystallization of Sodium Scutellarein by Combined FBRM-PVM-NIR
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کلمات کلیدی
Particle sizing - اندازه ذراتFocused beam reflectance measurement - اندازه گیری بازتابی پرتو متمرکز شدهCrystallization - بلورسازیImage analysis - تجزیه و تحلیل تصویرProcess analytical technology - تکنولوژی تحلیلی فرایندPartial least squares - حداقل مربعات جزئی Processing - در حال پردازشNear-infrared spectroscopy - طیف شناسی فروسرخ نزدیک
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Antisolvent crystallization can be used as an alternative to cooling or evaporation for the separation and purification of solid product in the pharmaceutical industry. To improve the process understanding of antisolvent crystallization, the use of in-line tools is vital. In this study, the process analytical technology (PAT) tools including focused beam reflectance measurement (FBRM), particle video microscope (PVM), and near-infrared spectroscopy (NIRS) were utilized to monitor antisolvent crystallization of sodium scutellarein. FBRM was used to monitor chord count and chord length distribution of sodium scutellarein particles in the crystallizer, and PVM, as an in-line video camera, provided pictures imaging particle shape and dimension. In addition, a quantitative model of PLS was established by in-line NIRS to detect the concentration of sodium scutellarein in the solvent and good calibration statistics were obtained (r2Â =Â 0.976) with the residual predictive deviation value of 11.3. The discussion over sensitivities, strengths, and weaknesses of the PAT tools may be helpful in selection of suitable PAT techniques. These in-line techniques eliminate the need for sample preparation and offer a time-saving approach to understand and monitor antisolvent crystallization process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 6, June 2011, Pages 2452-2459
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 6, June 2011, Pages 2452-2459
نویسندگان
Xuesong Liu, Di Sun, Feng Wang, Yongjiang Wu, Yong Chen, Longhu Wang,