کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486636 1114388 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rapid Solid-State Analysis of Freeze-Dried Protein Formulations Using NIR and Raman Spectroscopies
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Rapid Solid-State Analysis of Freeze-Dried Protein Formulations Using NIR and Raman Spectroscopies
چکیده انگلیسی
Noninvasive near-infrared (NIR) and Raman spectroscopies were applied to provide a fast and efficient insight into the formation of different mannitol solid forms occurring in freeze-dried formulations. Multivariate data analysis clearly showed the formation of δ-mannitol in the presence of protein, whereas β-mannitol was observed in the absence of protein.The multivariate analysis of the NIR spectra also gave an indication for the formation of mannitol hemihydrate in the absence of protein. Spectroscopic techniques in combination with multivariate analysis can be applied for fast screening and identification of excipient solid-state properties in pharmaceutical formulations. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:2871-2875, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 7, July 2011, Pages 2871-2875
نویسندگان
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