کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487087 | 1114403 | 2009 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of glycosylation on the stability of protein pharmaceuticals
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Biopharmaceutics - بیولوژیک داروییThermodynamics - ترمودینامیکPhysical stability - ثبات فیزیکیPhysicochemical properties - خواص فیزیکی و شیمیاییMolecular modeling - مدل سازی مولکولیBiophysical models - مدل های بیوفیزیکیStabilization - پایدارسازیChemical stability - پایداری شیمیاییProteins - پروتئین هاGlycosylation - گلیکوزیله شدن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of glycosylation on the stability of protein pharmaceuticals Effects of glycosylation on the stability of protein pharmaceuticals](/preview/png/2487087.png)
چکیده انگلیسی
In recent decades, protein-based therapeutics have substantially expanded the field of molecular pharmacology due to their outstanding potential for the treatment of disease. Unfortunately, protein pharmaceuticals display a series of intrinsic physical and chemical instability problems during their production, purification, storage, and delivery that can adversely impact their final therapeutic efficacies. This has prompted an intense search for generalized strategies to engineer the long-term stability of proteins during their pharmaceutical employment. Due to the well known effect that glycans have in increasing the overall stability of glycoproteins, rational manipulation of the glycosylation parameters through glycoengineering could become a promising approach to improve both the in vitro and in vivo stability of protein pharmaceuticals. The intent of this review is therefore to further the field of protein glycoengineering by increasing the general understanding of the mechanisms by which glycosylation improves the molecular stability of protein pharmaceuticals. This is achieved by presenting a survey of the different instabilities displayed by protein pharmaceuticals, by addressing which of these instabilities can be improved by glycosylation, and by discussing the possible mechanisms by which glycans induce these stabilization effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 4, April 2009, Pages 1223-1245
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 4, April 2009, Pages 1223-1245
نویسندگان
Ricardo J. Solá, Kai Griebenow,