کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487099 | 1114403 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pair distribution function Xâray analysis explains dissolution characteristics of felodipine melt extrusion products
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pair distribution function Xâray analysis explains dissolution characteristics of felodipine melt extrusion products Pair distribution function Xâray analysis explains dissolution characteristics of felodipine melt extrusion products](/preview/png/2487099.png)
چکیده انگلیسی
Solid solutions of felodipine with EUDRAGIT® E and EUDRAGIT® E/NE were shown to dramatically increase the dissolution rate of felodipine in biorelevant media. Of the two polymer systems, extrudates containing 5% EUDRAGIT® NE showed a faster dissolution rate and less recrystallization (no precipitation within 2 h). Although differential scanning calorimetry (DSC) and conventional Xâray powder diffraction (XRPD) were able to verify the amorphous state of the drug after melt extrusion, it was not possible to differentiate the two extrudate compositions further with these methods. We then applied pair distribution function (PDF) analysis to investigate extrudates. It was possible to more closely characterize the solid state of the amorphous extrudates in terms of local structural order: PDF analysis revealed that addition of minor amounts of EUDRAGIT® NE to the main component EUDRAGIT® E during extrusion changed the local structure of EUDRAGIT® E in a nonadditive way. We conclude that local ordering can be important to the release characteristics of extrudates, even when the components are present in the amorphous state. © 2008 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 98:1476-1486, 2009
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 4, April 2009, Pages 1476-1486
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 4, April 2009, Pages 1476-1486
نویسندگان
K. Nollenberger, A. Gryczke, Ch. Meier, J. Dressman, M.U. Schmidt, S. Brühne,