کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487157 | 1114406 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular mobility of nifedipineâPVP and phenobarbitalâPVP solid dispersions as measured by 13C-NMR spin-lattice relaxation time
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular mobility of nifedipineâPVP and phenobarbitalâPVP solid dispersions as measured by 13C-NMR spin-lattice relaxation time Molecular mobility of nifedipineâPVP and phenobarbitalâPVP solid dispersions as measured by 13C-NMR spin-lattice relaxation time](/preview/png/2487157.png)
چکیده انگلیسی
Amorphous nifedipineâPVP and phenobarbitalâPVP solid dispersions with various drug contents were prepared by melting and subsequent rapid cooling of mixtures of PVP and nifedipine, or phenobarbital. Chemical shifts and spin-lattice relaxation times (T1) of PVP, nifedipine, and phenobarbital carbons were determined by 13C-CP/MAS NMR to elucidate drugâPVP interactions and the localized molecular mobility of drug and PVP in the solid dispersions. The chemical shift of the PVP carbonyl carbon increased as the drug content increased, appearing to reach a plateau at a molar ratio of drug to PVP monomer unit of approximately 1:1, suggesting hydrogen bond interactions between the PVP carbonyl group and the drugs. T1 of the PVP carbonyl carbon in the solid dispersions increased as the drug content increased, indicating that the mobility of the PVP carbonyl carbon was decreased by hydrogen bond interactions. T1 of the drug carbons increased as the PVP content increased, and this increase in T1 became less obvious when the molar ratio of PVP monomer unit to drug exceeded approximately 1:1. These results suggest that the localized motion of the PVP pyrrolidone ring and the drug molecules is reduced by hydrogen bond interactions. Decreases in localized mobility appear to be one of the factors that stabilize the amorphous state of drugs. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 2, February 2006, Pages 318-325
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 2, February 2006, Pages 318-325
نویسندگان
Yukio Aso, Sumie Yoshioka,