کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487570 | 1114422 | 2007 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Use of Chitosan-Alginate as Alternative Pelletization Aid to mMicrocrystalline Cellulose in Extrusion/Spheronization
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Use of Chitosan-Alginate as Alternative Pelletization Aid to mMicrocrystalline Cellulose in Extrusion/Spheronization Use of Chitosan-Alginate as Alternative Pelletization Aid to mMicrocrystalline Cellulose in Extrusion/Spheronization](/preview/png/2487570.png)
چکیده انگلیسی
Two types of different molecular weight chitosan were investigated as a pelletization aid in extrusion/spheronization using water as granulation liquid. Spherical pellets with a maximum fraction of 60% w/w chitosan could be produced when 1.25-2.5% w/w sodium alginate was included in the formulations with no microcrystalline cellulose (MCC). Chitosan with lower molecular weight of 190 kDa showed a better pellet forming property. The pellets obtained had acceptable physical characteristics and a fast drug release. The results from Fourier transform infrared spectroscopy, differential scanning calorimetry and 13C CPâMAS nuclear magnetic resonance spectroscopy confirmed the formation of polyelectrolyte complex (PEC) between chitosan and sodium alginate, which might be a reason for successful pelletization by extrusion/spheronization. Moreover, the presence of PEC might influence the physical characteristics and dissolution behavior of chitosanâalginate pellets. The results indicated an achievement in production of pellets by extrusion/spheronization without using MCC. Moreover, chitosan combined with sodium alginate could be used as a promising alternative pelletization aid to MCC in extrusion/spheronization. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2469-2484, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2469-2484
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2469-2484
نویسندگان
Nattawut Charoenthai, Peter Kleinebudde, Satit Puttipipatkhachorn,