کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487663 | 1114426 | 2007 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Qualitative in situ analysis of multiple solidâstate forms using spectroscopy and partial least squares discriminant modeling
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کلمات کلیدی
Partial least squares discriminant analysis - تجزیه و تحلیل خرده مقیاس حداقل مربعات جزئیMultivariate analysis - تحلیل چندمتغیرهSolid state - حالت جامدDehydration - دهیدراسیون، کمآبی بدنRaman spectroscopy - طیف سنجی رامانnear‐infrared spectroscopy - طیف سنجی نزدیک به مادون قرمزHydrate - هیدراتPiroxicam - پیروکسیکامcarbamazepine - کاربامازپینTransition - گذار
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study used in situ spectroscopy to reveal the multiple solidâstate forms that appear during isothermal dehydration. Hydrate forms of piroxicam and carbamazepine (CBZ) were investigated on hotâstage at different temperatures using nearâinfrared (NIR) and Raman spectroscopy combined with multivariate modeling. Variable temperature Xâray powder diffraction, differential scanning calorimetry, thermogravimetric analysis, and Karl Fisher titrimetry were used as reference methods. Partial least squares discriminant analysis (PLSâDA) was performed to qualitatively evaluate the phase transition. It was shown that the constructed PLSâDA models, where spectral differences were directly correlated to solidâstate modifications, enabled differentiation between the multiple forms. Qualitative analysis revealed that during dehydration, hydrates, such as CBZ dihydrate, may go through several solidâstate forms, which must be considered in quantitative model construction. This study demonstrates that in situ analysis can be used to monitor the dehydration and reveal associated solidâstate forms prior to quantification. The utility of the complementary spectroscopic techniques, NIR and Raman, have been shown. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1802-1820, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 7, July 2007, Pages 1802-1820
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 7, July 2007, Pages 1802-1820
نویسندگان
Karin Kogermann, Jaakko Aaltonen, Clare J. Strachan, Kati Pöllänen, Peep Veski, Jyrki Heinämäki, Jouko Yliruusi, Jukka Rantanen,