کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487773 | 1114431 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of Characteristics of Compounds on Maintenance of an Amorphous State in Solid Dispersion with Crospovidone
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Solid dispersion (SD) of indomethacin with crospovidone (CrosPVP) shows useful characteristics for preparation of dosage forms. This study aimed to determine the types of drugs that could adopt a stable amorphous form in SD. Twenty compounds with various melting points (70-218°C), molecular weights (135-504) and functional groups (amide, amino, carbonyl, hydroxyl, ketone etc.) were prepared in SD with CrosPVP. The CrosPVP SDs were prepared using a mechanical mixing and heating method. Melting point and molecular weight were found to have no influence on the ability of a compound to maintain an amorphous state in SD. All compounds containing hydrogenâbondâdonor functional groups existed in an amorphous state in SD for at least 6 months. Infrared spectra suggested an interaction between the functional groups of these compounds and amide carbonyl group of CrosPVP. Compounds without hydrogenâbondâdonor groups could not maintain an amorphous state and underwent recrystallization within 1 month. It was suggested that the presence of a hydrogenâbondâdonor functional group in a compound is an important factor affecting the stable formation of SD with CrosPVP, which contains a hydrogenâbond acceptor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 6, June 2007, Pages 1537-1547
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 6, June 2007, Pages 1537-1547
نویسندگان
Yusuke Shibata, Makiko Fujii, Makiko Kokudai, Shinobu Noda, Hideko Okada, Masuo Kondoh, Yoshiteru Watanabe,