کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487845 | 1114437 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A New Tetrahydrated Form of Sodium Naproxen
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The anhydrous sodium naproxen (ASN) can form several hydrated phases if maintained at different relative humidities (RH). The water uptake can promote crystallographic modifications, according to the amount of water. In a previous work, the authors showed that a dihydrated form could be obtained either by crystallization in water or by exposure of the anhydrous form to a RH of 55%. In the present work, the authors report about the formation and characterization of a new tetrahydrated form, obtained by exposing the ASN to RH â¥Â 75%. All the hydrated compounds were characterized by the combined use of several spectroscopic, thermal, and crystallographic techniques. The thermal stability of both the dihydrated and tetrahydrated compounds was also tested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 1, January 2007, Pages 156-167
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 1, January 2007, Pages 156-167
نویسندگان
Piera Di Martino, Christine Barthélémy, Etienne Joiris, Doretta Capsoni, Admir Masic, Vincenzo Massarotti, Roberto Gobetto, Marcella Bini, Sante Martelli,