کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2488133 | 1114459 | 2006 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thermodynamic Stability and Crystal Structures for Polymorphs and Solvates of Formoterol Fumarate
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Thermodynamic Stability and Crystal Structures for Polymorphs and Solvates of Formoterol Fumarate Thermodynamic Stability and Crystal Structures for Polymorphs and Solvates of Formoterol Fumarate](/preview/png/2488133.png)
چکیده انگلیسی
Polymorph screening of formoterol fumarate was performed in 12 solvents, followed by evaluations of thermodynamic stability. Three anhydrates, a dihydrate, a diethanolate, a diisopropanolate, and a dibensylalcoholate were found. The crystal structure of three solvated modifications and of the most stable anhydrate was investigated. This indicated that solvation is needed to get a stable and well packed crystal structure. Thermodynamic testing suggests that five crystal modifications are thermodynamically stable, at different conditions, since they are all reversibly related to each other.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 5, May 2006, Pages 1144-1161
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 5, May 2006, Pages 1144-1161
نویسندگان
K. Jarring, T. Larsson, B. Stensland, I. Ymén,