کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2498256 1556738 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A hydrophobic peptide fraction that enhances the water dispersibility of curcumin
ترجمه فارسی عنوان
یک بخش پپتیدی هیدروفی فیبری است که باعث افزایش پراکندگی آب کورکومین می شود
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

The present study describes the complexation between curcumin (Cur) and a peptide mixture (Pep). Pep was prepared by enzymatic hydrolysis of casein and used as an excipient for poorly water-soluble Cur. An aqueous solution of Pep and an acetone solution of Cur were mixed and lyophilized to obtain a white-yellow powder of the peptide and Cur complex (Cur-Pep). The water dispersibility of Cur was enhanced by the complexation with Pep. Pep was fractionated using ammonium sulfate precipitation and ultrafiltration to identify which peptides preferentially interact with Cur. Relatively hydrophobic peptides with high molecular weights (>5 kDa) were more effective in enhancing the water dispersibility of Cur than other fractions. Cur-Pep dispersed under acidic and neutral conditions, at which amphoteric Pep is positively or negatively charged. Cur-Pep exists as a hydrocolloid with particle size 160–330 nm in aqueous media.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Pharmaceutical Sciences - Volume 11, Issue 5, October 2016, Pages 631–640
نویسندگان
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