کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2500862 | 1557316 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and potential application of an oral ColoPulse infliximab tablet with colon specific release: A feasibility study
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The monoclonal antibody infliximab is one of the cornerstones in the treatment of Crohn’s disease. Local delivery of infliximab would be an alternative to overcome the inherent disadvantages of intravenous therapy. For this purpose 5 mg infliximab tablets were developed. To stabilize the antibody during production and storage it was incorporated in a sugar glass containing the oligosaccharide inulin. To obtain colon-specific release a ColoPulse coating was applied. The tablets were stored for 16 months under different conditions based on ICH climatic zone I:
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 505, Issues 1–2, 30 May 2016, Pages 175–186
Journal: International Journal of Pharmaceutics - Volume 505, Issues 1–2, 30 May 2016, Pages 175–186
نویسندگان
Jacoba M. Maurer, Susan Hofman, Reinout C.A. Schellekens, Wouter F. Tonnis, Annelien O.T. Dubois, Herman J. Woerdenbag, Wouter L.J. Hinrichs, Jos G.W. Kosterink, Henderik W. Frijlink,