کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501218 1557327 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roxithromycin-loaded lipid nanoparticles for follicular targeting
ترجمه فارسی عنوان
نانوذرات لیپیدی لایه بردار روکشیدرومایسین برای هدف گیری فولیکولار
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Particulate drug carriers e.g. nanoparticles (NPs) have been shown to penetrate and accumulate preferentially in skin hair follicles creating high local concentration of a drug. In order to develop such a follicle targeting system we obtained and characterized solid lipid nanoparticles (SLN) loaded with roxithromycin (ROX). The mean particle size (172 ± 2 nm), polydisperisty index (0.237 ± 0.007), zeta potential (−31.68 ± 3.10 mV) and incorporation efficiency (82.1 ± 3.0%) were measured. The long term stability of ROX-loaded SLN suspensions was proved up to 26 weeks. In vitro drug release study was performed using apparatus 4 dialysis adapters. Skin irritation test conducted using the EpiDerm™ tissue model demonstrated no irritation potential for ROX-loaded SLN. Ex vivo human skin penetration studies, employing rhodamine B hexyl ester perchlorate (RBHE) as a fluorescent dye to label the particles, revealed fluorescence deep in the skin, specifically around the hair follicles up to over 1 mm depth. The comparison of fluorescence intensities after application of RBHE solution and RBHE-labelled ROX-loaded SLN was done. Then cyanoacrylate follicular biopsies were obtained in vivo and analyzed for ROX content, proving the possibility of penetration to human pilosebaceous units and delivering ROX by using SLN with the size below 200 nm.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 495, Issue 2, 30 November 2015, Pages 807–815
نویسندگان
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