کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501400 1557335 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of the oral bioavailability of silymarin-loaded lipid nanoparticles with their artificial lipolysate counterparts: implications on the contribution of integral structure
ترجمه فارسی عنوان
مقایسه زیستپذیری خوراکی نانو ذرات لیپید سیلیمارین با همتایان مصنوعی لیپولیزات: نتیجه گیری در مورد نقش ساختار انتگرال
کلمات کلیدی
نانوذرات لیپید، دهانی، قابلیت دسترسی بیولوژیک، تحویل مواد مخدر، لیپولیز
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Both solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were artificially broken down into lipolysates. Their oral bioavailability, with silymarin as a model drug, was compared in dogs to highlight the contribution of their integral structure. The lipid nanoparticles were prepared using a conventional hot homogenization method, whereas the lipolysates were obtained through lipolysis in phospholipid- and bile salt-enriched simulated intestinal fluid. More than 80% of vehicle-associated drugs could be transformed into the water-soluble form of mixed micelles. Pharmacokinetics analysis in dogs showed a decrease in bioavailability of 74.86% and 59.09% for lipolysates compared to integral NLCs and SLNs, respectively. It was indicated that lipolysates contributed to a majority of drug absorption. Integral nanoparticles were superior to their lipolysate counterparts, but only marginally; if the approximately 20% of the drug that precipitated during in vitro lipolysis was deducted from the overall absorption amount, the superiority of integral nanoparticles would be significantly compromised. In conclusion, lipolysis was the predominant in vivo absorption mechanism, and the contribution of intact lipid nanoparticles was limited.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 489, Issues 1–2, 15 July 2015, Pages 195–202
نویسندگان
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