کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501401 1557335 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Asymmetric lipid–polymer particles (LIPOMER) by modified nanoprecipitation: role of non-solvent composition
ترجمه فارسی عنوان
نانو ذرات لیپید نامتقارن (لیپومر) توسط نانو اکسایش تغییر یافته: نقش ترکیب غیر حلال
کلمات کلیدی
ذرات پلیمری لیپید نامتقارن (لیپومر)، اثر مارانگونی، قطبی، تصویربرداری در زمان واقعی، ریخته گری سیال
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Asymmetric lipid polymer nanostructures (LIPOMER) comprising glyceryl monostearate (GMS) as lipid and Gantrez AN 119 (Gantrez) as polymer, revealed enhanced splenic accumulation. In the present paper, we attempt to explain the formation of asymmetric GMS LIPOMER using real time imaging. Particles were prepared by precipitation under static conditions using different non-solvent phase compositions. The process was video recorded and the videos converted to time elapsed images using the FFmpeg 0.10.2 software at 25frames/sec. Non-solvent compositions comprising >30% of IPA/Acetone revealed significant stranding of the solvent phase and slower onset of precipitation(2–6 s). At lower concentrations of IPA and acetone, and in non-solvent compositions comprising ethanol/water the stranding phenomenon was not evident. Further, rapid precipitation(<1 s) was evident. Nanoprecipitation based on the Marangoni effect is a result of diffusion stranding, interfacial turbulence, and mass transfer of solvent and non-solvent resulting in solute precipitation. Enhanced diffusion stranding favored by high interaction of GMS and Gantrez(low ΔPol), and the low solubility parameter(Δδtotal) and high mixing enthalpy(ΔHM) of GMS in IPA resulted in droplets with random shapes analogous to an amoeba with pseudopodia, which on precipitation formed asymmetric particles. Asymmetric particles could be readily designed through appropriate selection of solutes and non-solvent phase by modified nanoprecipitation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 489, Issues 1–2, 15 July 2015, Pages 246–251
نویسندگان
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