Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment

• The developed double-layer adhesive silicone film (DLASil) for pharmaceutical application is presented.
• To access medical application, various properties were examined.
• The properties: adhesion, occlusion, hydration, oxygen permeation, water vapor permeation are important to treatment of keloids and hypertrophic or burn scars.
• Double-layer adhesive silicone film containing enoxaparin (LMWH) as an active substance is a new solution for effective therapy of hypertrophic scars, keloids and burn scars.

The present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as in vitro adhesion and occlusion related to in vivo hydration. From the silicone rubbers double layer silicone film was prepared: a non-adhesive elastomer as a drug carrier (the matrix for active substances – enoxaparin sodium – low molecular weight heparin) and an adhesive elastomer, applied on the surface of the matrix. The novel adhesive silicone film was found to possess optimal properties in comparison to commercially available silicone dressing: adhesion in vivo, adhesion in vitro – 11.79 N, occlusion F = 85% and water vapor permeability in vitro – WVP = 105 g/m2/24 h, hydration of stratum corneum in vivoH = 61–89 (RSD = 1.6–0.9%), oxygen permeation in vitro – 119–391 cm3/m2/24 (RSD = 0.17%). In vitro release studies indicated sufficient LMWH release rate from silicone matrix. Developed novel adhesive silicone films were considered an effective treatment of scars and keloids and a potential drug carrier able to improve the effectiveness of therapy.

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