کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501568 1557346 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles
چکیده انگلیسی

Phenylboronic acid-rich nanoparticles (PBNPs) were designed as a novel mucoadhesive vaginal drug delivery system. PBNPs effectively adsorbed mucin in vitro and could be easily loaded with the model drug interferon (IFN). Drug release from PBNPs was controlled by the presence of mucin. Neither obvious cytotoxicity nor vaginal histological changes in mice caused by PBNPs or IFN-loaded PBNPs were observed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 479, Issue 1, 1 February 2015, Pages 261–264
نویسندگان
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