کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501675 1557351 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study on formability of solid nanosuspensions during solidification: II novel roles of freezing stress and cryoprotectant property
ترجمه فارسی عنوان
بررسی شکل پذیری نانوساختارهای جامد در طی خنثی سازی: دومین نقش ریشه ای استرس انجماد و ویژگی های حفاظتی
کلمات کلیدی
نانوساختارهای جامد، نانوکریستال، استرس انجماد، جداسازی تثبیت کننده کریستال، فریبنده ها، فشار اسمزی، ریزپوشش پذیری
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

The freezing stress and cryoprotectants were known to be the crucial factors for solidification formability of nanosuspensions during freeze-drying. However, there has been controversy as to whether an aggressive or conservative freezing stress (freezing temperature or freezing rate) prevents from irreversible aggregation of nanosuspensions. And the screening of cryoprotectants for solidification formability of nanosuspensions has largely relied on empirical approaches. A systematic investigation was presented herein regarding the effect of both the freezing stress and property of cryoprotectants on solidification formability of drug nanosuspensions during freeze-drying. It was found that at different freezing stresses (−20 °C, −80 °C, and −196 °C), the redispersibility of BCN, NGN, RCN, and RVL nanosuspensions stabilized, respectively, by seven stabilizers, was RDI−20 °C > RDI−80 °C > RDI−196 °C. But the redispersibility of UDCA and OCA nanosuspensions stabilized, respectively, by seven stabilizers, was RDI−20 °C < RDI−80 °C < RDI−196 °C. These phenomena could be explained by proposed novel crystal-stabilizer separation hypothesis in nano-concentrated phase during freezing, based on freezing rate, the diffusion characteristics of the drug crystals and stabilizer molecules. The two key properties of cryoprotectant that played an important role on the formability of nanosuspensions during freeze-drying were glass transition temperature and osmotic pressure. The cryoprotectant candidates with moderate π and Tg values, sucrose achieved the excellent solidification formability of drug nanosuspensions. And the firstly proposed classify guideline based on roles of freezing stress and cryoprotectant property could give a reference for process screening of solid nanosuspensions. This study will facilitate an in-depth understanding of formability of solid nanosuspensions during freeze-drying.

Figure optionsDownload high-quality image (226 K)Download as PowerPoint slideThe proposed classify guideline of drug nanocrystals based on roles of freezing stress and cryoprotectant property.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 475, Issues 1–2, 20 November 2014, Pages 35–48
نویسندگان
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