کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501714 1557350 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Visceral mesh modified with cyclodextrin for the local sustained delivery of ropivacaine
ترجمه فارسی عنوان
مش اسرارآمیز با سیکلوکودکسترون اصلاح شده برای تحویل موضعی روپیفوواکائین است
کلمات کلیدی
اصلاح سطح، مش پارچه ای مشکی، سیکلوکودکسترین، بی حسی موضعی، روپویاکائین، تحویل طولانی مدت
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

The aim of the study was to develop a polyester visceral implant modified with a cyclodextrin polymer for the local and prolonged delivery of ropivacaine to reduce post operatory pain. Therefore, we applied a coating of an inguinal mesh with a crosslinked polymer of hydroxypropyl-β-cyclodextrin (HPβCD) whose specific host–guest complex forming properties were expected to improve the adsorption capacity of the implant toward anesthetic, and then to release it within a sustained period.The modification reaction of the textile with cyclodextrin was explored through the study of the influence of the pad/dry/cure process parameters and the resulting implant (PET–CD) was characterized by solid state NMR and SEM. Besides, the inclusion complex between ropivacaine and CD was studied by NMR and capillary electrophoresis in PBS medium. Finally, ropivacaine sorption test showed that a maximum of 30 mg/g of ropivacaine could be adsorbed on the functionalized samples. In dynamic batch tests in PBS at pH 7.4, the release could be observed up to 6 h. The cytocompatibility of the PET–CD loaded with ropivacaine was also studied and reached 65% cell vitality after 6 days.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 476, Issues 1–2, 10 December 2014, Pages 149–159
نویسندگان
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