کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501744 1557347 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vaginal inserts based on chitosan and carboxymethylcellulose complexes for local delivery of chlorhexidine: Preparation, characterization and antimicrobial activity
ترجمه فارسی عنوان
درج واژن بر پایه ترکیبات کیتوزان و کربوکسی متیل سلولز برای تحویل محلی کلرهگزیدین: آماده سازی، مشخص کردن و فعالیت ضد میکروبی
کلمات کلیدی
کیتوزان، کربوکسی متیل سلولز، مجتمع های پلی الکترولیتی، کلرهگزیدین دیگو لوونات، درج واژن، فعالیت ضد میکروبی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

The aim of this work was to prepare vaginal inserts based on chitosan/carboxymethylcellulose polyelectrolyte complexes for local delivery of chlorhexidine digluconate. Complexes were prepared with different chitosan/carboxymethylcellulose molar ratios at a pH value close to pKa interval of the polymers and were characterized in terms of physico-chemical properties, complexation yield and drug loading. Then complexes were used to prepare inserts as vaginal dosage forms and their physical handling, morphology, water-uptake ability and drug release properties as well as antimicrobial activity toward Candida albicans and Escherichia coli were evaluated. Results confirmed the ionic interaction between chitosan and carboxymethylcellulose and the influence of the charge amount on the complexation yield. Complexes were characterized by high values of drug loading and showed increasing water-uptake ability with the increase of carboxymethylcellulose amount. The selection of appropriate chitosan/carboxymethylcellulose molar ratios allowed to obtain cone-like shaped solid inserts, easy to handle and able to hydrate releasing the drug over time. Finally, the formulated inserts showed antimicrobial activity against common pathogens responsible for vaginal infections.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 478, Issue 2, 30 January 2015, Pages 456–463
نویسندگان
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