کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2501915 | 1557367 | 2014 | 8 صفحه PDF | دانلود رایگان |
There are no test procedures, definitions and specifications available how to determine mechanical strength of orodispersible or buccal films. Aim of the study was to develop an appropriate and discriminating method to feature the evaluation of marketed and newly developed film products covering well-known and new approaches. The limits for mechanical strength were set starting from a puncture strength of 0.06 N/mm2 according to the obtained results from marketed products. Furthermore, elongation to break of the marketed films (1.03–6.54%) and prepared film samples (4.51–33.17%) offered information on the film properties. The developed mechanical strength test method was suitable for all film types without the need of a pre-defined specimen. A mechanical strength threshold could be specified for future orodispersible film development.
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Journal: International Journal of Pharmaceutics - Volume 461, Issues 1–2, 30 January 2014, Pages 22–29