کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2502154 | 1557374 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A new highly viscoelastic hyaluronic acid gel: rheological properties, biocompatibility and clinical investigation in esthetic and restorative surgery A new highly viscoelastic hyaluronic acid gel: rheological properties, biocompatibility and clinical investigation in esthetic and restorative surgery](/preview/png/2502154.png)
Nowadays there is an increased demand for safe and effective volume enhancing fillers to achieve soft tissue augmentation in order to overcome tissue defects and aging-associated skin changes. In the present study we characterized the rheological and biological properties of Variofill®, a new highly viscoelastic hyaluronic acid gel, by investigating the local effects following subcutaneous implantation in the rat to detect the host-tissue reactions and biodegradation over 18 months. We also investigated, for the first time, the application of Variofill® in esthetic and restorative surgery in two medical case reports. In the first case report we successfully performed Variofill® treatment to improve facial scars in a patient previously involved in a car crash. In the second case report we carried out a novel procedure involving a high-dose (1000 ml) injection of Variofill® into the dermis and subcutis of the abdominal quadrants in order to allow a classic reconstructive procedure of the abdominal wall in a patient presenting a wide incisional hernia.
Eighteen months post-implantation, hyaluronic acid gel is partially absorbed. Hyaluronic acid gel is pooled into metachromatic vacuoles surrounded by fibrous strands and only slight infiltration of inflammatory cells.Figure optionsDownload high-quality image (326 K)Download as PowerPoint slide
Journal: International Journal of Pharmaceutics - Volume 456, Issue 2, 18 November 2013, Pages 583–592